ITGB1BP2抗体;ITGB1BP2 Antibody—艾普蒂

+ +

•  

   

     Western blot analysis using ITGB1BP2 mouse mAb against  rat skeletal muscle lysate    

  
  

•  

   

     Lane 1: Rat skeletal muscle tissue lysate;  Lane 2: ITGB1BP2 immunoprecipitated from rat skeletal muscle tissue lysate by P15128 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15128 can immunoprecipitate ITGB1BP2;    

  
  

The ITGB1BP2 antibody targets the integrin beta-1 binding protein 2 (ITGB1BP2), also known as BETA3-binding protein 2 or C9orf21. This protein interacts with integrin β1 subunits, which are critical components of cell adhesion receptors involved in cell-matrix interactions, signaling, and cellular processes like migration, proliferation, and survival. ITGB1BP2 contains a pleckstrin homology (PH) domain, suggesting roles in lipid binding or membrane localization. Its precise biological function remains under investigation, though studies imply involvement in regulating integrin-mediated signaling pathways, potentially influencing cancer progression, fibrosis, or immune responses.

ITGB1BP2 antibodies are essential tools for detecting and quantifying the protein in research applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They enable exploration of ITGB1BP2 expression patterns across tissues and its dysregulation in diseases. For example, altered ITGB1BP2 levels have been observed in certain cancers, where it may modulate tumor cell adhesion or metastasis. Antibody specificity is typically validated using knockout controls or siRNA-mediated knockdown to ensure accurate detection. Commercially available antibodies are often developed in hosts like rabbits or mice, with reactivity spanning human, mouse, and rat samples. Research utilizing these antibodies aims to clarify ITGB1BP2's role in integrin signaling networks and its potential as a therapeutic target or biomarker in pathological conditions.