HARS1抗体;HARS1 Antibody—艾普蒂 新品

+ +

•  

   

     IHC-P analysis of salivary gland tissue by HARS1 antibody (P15111) IHC-P was performed using sections of the formalin-fixed paraffin-embedded salivary gland tissue;Result: Glandular cells are positively stained at the cytoplasm.    

  
  

The histidyl-tRNA synthetase 1 (HARS1) is a member of the aminoacyl-tRNA synthetase (ARS) family, enzymes critical for protein synthesis that catalyze the attachment of specific amino acids to their cognate tRNAs. HARS1 specifically charges tRNA^His with histidine, ensuring translational fidelity. Beyond its canonical role, HARS1 participates in non-catalytic functions, including immune signaling and RNA processing. Mutations in the *HARS1* gene are linked to inherited peripheral neuropathies, such as Charcot-Marie-Tooth disease type 2W (CMT2W), characterized by axonal degeneration and sensory-motor impairments.

Autoantibodies targeting HARS1. notably anti-Jo-1 antibodies, are hallmark biomarkers in autoimmune disorders like antisynthetase syndrome (ASS), which manifests with myositis, interstitial lung disease, and arthritis. These autoantibodies arise from immune dysregulation, though their pathogenic role remains debated; they may exacerbate inflammation by forming immune complexes or modulating enzyme activity.

Research-grade HARS1 antibodies are pivotal tools for studying its expression, localization, and mutation-associated dysfunction. They also aid in diagnosing autoimmune conditions or genetic disorders. Recent studies explore HARS1’s interaction partners and roles in cellular stress responses, highlighting its therapeutic potential. Understanding HARS1 biology and its antibodies advances both mechanistic insights into neuropathies/autoimmunity and the development of targeted diagnostics or treatments.

(Word count: 199)