RGL2抗体;RGL2 Antibody—艾普蒂 新品

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     IHC-P analysis of stomach tissue by RGL2 antibody (P15103) IHC-P was performed using sections of the formalin-fixed paraffin-embedded stomach tissue;Result: Glandular cells are positively stained at the cytoplasm.    

  
  

**Background of RGL2 Antibody**

RGL2 (Ral Guanine Nucleotide Dissociation Stimulator-Like 2), a member of the RalGEF family, is a Ras superfamily-associated protein implicated in intracellular signaling pathways. It functions as a guanine nucleotide exchange factor (GEF) for RalA and RalB GTPases, facilitating their activation by promoting the exchange of GDP for GTP. RGL2 is involved in diverse cellular processes, including vesicle trafficking, cell migration, proliferation, and survival. Its interaction with activated Ras proteins links upstream signals to downstream Ral-mediated pathways, which are critical in cancer progression, neuronal development, and immune regulation.

RGL2 antibodies are immunological tools designed to detect and study the expression, localization, and functional roles of RGL2 in biological systems. These antibodies are widely used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to investigate RGL2's involvement in diseases like cancer, where Ral pathway dysregulation is often observed. For instance, elevated RGL2 expression has been associated with tumor growth and metastasis in certain malignancies.

Developed using immunogenic peptides or recombinant RGL2 proteins, high-quality RGL2 antibodies exhibit specificity validated through knockout controls or siRNA knockdown experiments. Commercial RGL2 antibodies are available from multiple suppliers (e.g., Sigma-Aldrich, Abcam, CST) and are essential for elucidating RGL2's regulatory mechanisms and therapeutic potential in precision medicine research.