SPATA2L抗体;SPATA2L Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cell lysate, Primary antibody: P13856(SPATA2L Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

SPATA2L (Spermatogenesis-Associated Protein 2-Like) is a relatively understudied protein implicated in cellular processes such as apoptosis, inflammation, and ubiquitination pathways. It shares homology with SPATA2. a known regulator of the CYLD-RIPK1 signaling complex, which modulates NF-κB activation and necroptosis. SPATA2L is hypothesized to interact with similar molecular partners, potentially influencing cell survival and death mechanisms. However, its precise biological functions and regulatory mechanisms remain unclear.

SPATA2L antibodies are essential tools for investigating the protein's expression, localization, and interactions in various tissues and disease models. These antibodies are typically developed in immunized host species (e.g., rabbits or mice) using peptide antigens derived from conserved regions of the human SPATA2L protein. Validation often includes Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to confirm specificity and cross-reactivity across species.

Research utilizing SPATA2L antibodies has linked the protein to cancer progression, neurodegenerative disorders, and male infertility, though evidence is preliminary. For instance, altered SPATA2L expression has been observed in certain tumors, suggesting a role in oncogenic signaling or therapy resistance. Additionally, its potential involvement in ubiquitin-dependent pathways highlights its relevance in proteostasis and inflammation-related diseases. Further studies with high-quality antibodies are critical to unraveling SPATA2L's functional significance and therapeutic potential.