SYP抗体;SYP Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Human cerebella tissue lysates, Primary antibody: P13819(SYP Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P13819(SYP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

Synaptophysin (SYP) is a 38 kDa glycoprotein predominantly found in presynaptic vesicles of neurons and neuroendocrine cells. As a key component of synaptic transmission machinery, it facilitates the packaging, trafficking, and release of neurotransmitters. Structurally, SYP contains four transmembrane domains and forms complexes with other vesicle proteins, influencing synaptic plasticity and cognitive functions.

SYP antibodies are widely used as immunohistochemical markers to identify neuroendocrine and neuronal tissues in research and diagnostics. Their specificity makes them valuable for detecting tumors of neuroendocrine origin, such as neuroblastoma, pheochromocytoma, and small cell lung carcinoma. In research, SYP antibodies help study synaptic development, neurodegenerative diseases (e.g., Alzheimer’s), and psychiatric disorders linked to synaptic dysfunction.

First characterized in the 1980s, SYP antibodies are commonly applied in Western blotting, immunofluorescence, and electron microscopy. Their reliability stems from SYP’s conserved expression across species and resistance to fixation methods. However, interpretation requires caution, as non-neuroendocrine tissues (e.g., adrenal cortex) may show weak cross-reactivity. Ongoing studies explore SYP’s role in exosome biology and its potential as a therapeutic target, further cementing its relevance in neuroscience and oncology.