C1QBP抗体;C1QBP Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: RAW264.7, 293T cell lysates, Primary antibody: P13813(C1QBP Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13813(C1QBP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13813(C1QBP Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

C1QBP (Complement Component 1 Q Subcomponent-Binding Protein), also known as gC1qR, p32. or HABP1. is a multifunctional mitochondrial and cell-surface protein implicated in diverse physiological and pathological processes. Structurally, it forms a trimeric complex and interacts with numerous ligands, including complement C1q, coagulation factors, and viral proteins. C1QBP is ubiquitously expressed, with high levels in immune cells, endothelial cells, and certain cancer cells. It plays roles in complement activation, inflammation regulation, apoptosis, and mitochondrial metabolism.

C1QBP antibodies are essential tools for detecting and localizing this protein in research. They enable investigations into its involvement in diseases such as cancer, autoimmune disorders, and infections. For instance, C1QBP overexpression in tumors correlates with metastasis and poor prognosis, making it a potential therapeutic target. In autoimmune conditions, C1QBP modulates immune-complex clearance via complement pathways. Additionally, pathogens like HIV and hepatitis viruses exploit C1QBP for cellular entry, highlighting its significance in infectious disease mechanisms.

These antibodies are widely used in techniques like Western blot, immunohistochemistry, and flow cytometry. Their specificity helps unravel C1QBP's dual roles in homeostasis and disease, supporting drug development and biomarker discovery. Research continues to explore its regulatory networks and therapeutic applications.