CHD4抗体;CHD4 Antibody—艾普蒂

The CHD4 antibody is a crucial tool for studying the chromodomain helicase DNA-binding protein 4 (CHD4), a member of the CHD family of ATP-dependent chromatin remodelers. CHD4 plays a central role in epigenetic regulation by altering chromatin structure to modulate gene expression. It serves as the catalytic core of the Nucleosome Remodeling and Deacetylase (NuRD) complex, which couples histone deacetylation with chromatin remodeling to repress transcription. CHD4 is involved in diverse cellular processes, including DNA damage repair, cell cycle control, and differentiation. Dysregulation of CHD4 has been linked to cancers (e.g., endometrial, ovarian, and breast cancers), neurodevelopmental disorders, and cardiovascular diseases. Antibodies targeting CHD4 enable researchers to investigate its expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Specific CHD4 antibodies are also used to explore its role in maintaining genomic stability and its potential as a therapeutic target. Validation of these antibodies is critical due to structural similarities among CHD family members. Recent studies highlight CHD4's context-dependent dual roles as both an oncogene and tumor suppressor, underscoring the importance of reliable research tools to unravel its complex biological functions.