LAMB1抗体;LAMB1 Antibody—艾普蒂

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P13809(LAMB1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13809(LAMB1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The LAMB1 antibody targets laminin subunit beta-1 (LAMB1), a critical component of laminins—a family of heterotrimeric glycoproteins in the extracellular matrix (ECM). Laminins, composed of α, β, and γ chains, play essential roles in cell adhesion, differentiation, and tissue organization. Specifically, LAMB1 combines with α and γ subunits (e.g., laminin-111. laminin-211) to form structural networks in basement membranes, influencing tissue integrity and cellular signaling.

LAMB1 is widely expressed in epithelial, endothelial, and neural tissues. Dysregulation of LAMB1 is linked to pathologies such as skin blistering disorders (e.g., junctional epidermolysis bullosa), cancer progression (enhanced metastasis via ECM remodeling), and kidney diseases. Antibodies against LAMB1 are vital tools for studying its expression, localization, and function in normal and diseased states. They are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize basement membrane structures or assess LAMB1's role in cell-ECM interactions.

Research also explores LAMB1's potential as a biomarker or therapeutic target, particularly in cancers where its overexpression correlates with poor prognosis. However, challenges remain in distinguishing LAMB1-specific signals from cross-reactivity with other laminin isoforms. Validated LAMB1 antibodies are thus crucial for advancing mechanistic insights into ECM biology and associated diseases.