NTF3抗体;NTF3 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13806(NTF3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13806(NTF3 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

Neurotrophin 3 (NTF3), also known as NT-3. is a member of the neurotrophin family of growth factors critical for neuronal survival, differentiation, and synaptic plasticity. It binds to the tropomyosin receptor kinase C (TrkC) receptor and the pan-neurotrophin receptor p75NTR, activating downstream signaling pathways involved in neural development, particularly in the peripheral and central nervous systems. NTF3 supports the survival of sensory neurons, regulates neurotransmitter release, and contributes to processes like axonal growth and synaptic connectivity.

NTF3 antibodies are essential tools for detecting and quantifying NTF3 protein expression in research. These antibodies are widely used in techniques such as immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to study NTF3 localization, expression patterns, and regulatory roles in both physiological and pathological contexts. Dysregulation of NTF3 has been implicated in neurodegenerative diseases (e.g., Alzheimer’s), psychiatric disorders, and chronic pain, making its detection pivotal for understanding disease mechanisms.

Commercial NTF3 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes of the mature or precursor forms. Researchers must validate antibody specificity using knockout controls or blocking peptides to avoid cross-reactivity with related neurotrophins (e.g., BDNF, NGF). Reliable NTF3 antibodies enable investigations into its therapeutic potential, including roles in nerve regeneration or as biomarkers for neurological conditions.