ETV1抗体;ETV1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: P08483(LCP1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

The ETV1 antibody is a crucial tool in studying the ETS translocation variant 1 (ETV1) protein, a member of the ETS family of transcription factors. ETV1 regulates gene expression by binding to DNA through its conserved ETS domain and plays roles in cellular processes such as proliferation, differentiation, and apoptosis. It is activated by signaling pathways like MAPK/ERK and is implicated in cancer development when dysregulated. For example, ETV1 overexpression or chromosomal translocations (e.g., TMPRSS2-ETV1 in prostate cancer) drive oncogenesis by promoting cell survival, invasion, and metastasis. ETV1 is also linked to gastrointestinal stromal tumors (GISTs) and melanoma.

ETV1 antibodies are widely used in research to detect ETV1 expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help identify ETV1's role in tumor progression, its interaction with signaling pathways, and its potential as a therapeutic target or biomarker. In diagnostics, ETV1 antibodies aid in classifying cancers with ETV1 alterations, guiding personalized treatment strategies. However, challenges remain in ensuring antibody specificity due to structural similarities among ETS family members. Ongoing research focuses on refining antibody validation and exploring ETV1's therapeutic modulation in precision oncology.