PRKACB抗体;PRKACB Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse testis tissue lysate, Primary antibody: P13787(PRKACB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13787(PRKACB Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13787(PRKACB Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PRKACB antibody is a crucial tool for studying the protein kinase A catalytic subunit beta (PRKACB), a key component of the cAMP-dependent protein kinase (PKA) signaling pathway. PRKACB encodes the beta isoform of the catalytic subunit of PKA, a serine/threonine kinase that mediates cellular responses to cyclic AMP (cAMP). PKA regulates diverse processes, including metabolism, gene expression, and cell proliferation, by phosphorylating downstream targets. The PRKACB isoform is highly expressed in the brain, particularly in regions associated with learning and memory, suggesting its role in neuronal signaling and synaptic plasticity.

Antibodies targeting PRKACB enable researchers to detect and quantify its expression, localization, and activity in tissues or cell lines. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PRKACB's involvement in diseases. Dysregulation of PRKACB has been linked to neurological disorders, cancers, and metabolic syndromes. For example, mutations or altered expression may contribute to tumor progression or neurodevelopmental conditions.

PRKACB-specific antibodies also aid in distinguishing between PKA isoforms (e.g., PRKACA vs. PRKACB), which share structural similarities but may have tissue-specific functions. Their application extends to drug discovery, biomarker validation, and mechanistic studies of cAMP-PKA signaling. Robust validation of these antibodies ensures specificity, minimizing cross-reactivity with other PKA subunits, thus supporting accurate experimental outcomes in both basic and clinical research.