NUMA1抗体;NUMA1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P13786(NUMA1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The NUMA1 (Nuclear Mitotic Apparatus Protein 1) antibody targets the NUMA1 protein, a large structural component of the nuclear matrix involved in maintaining nuclear architecture and mitotic spindle organization during cell division. NUMA1. encoded by the *NUMA1* gene, contains coiled-coil domains that mediate its self-assembly and interaction with dynein/dynactin complexes, ensuring proper spindle pole formation. During interphase, NUMA1 localizes to the nucleus, contributing to nuclear integrity, and redistributes to spindle poles during mitosis to anchor microtubules.

NUMA1 antibodies are widely used in research to study cell cycle dynamics, nuclear organization, and mitotic errors. In diagnostic contexts, anti-NUMA1 autoantibodies are detected in autoimmune disorders, notably in a subset of systemic lupus erythematosus (SLE) patients, where they correlate with specific clinical manifestations. Additionally, NUMA1 dysregulation or chromosomal translocations involving *NUMA1* (e.g., t(11;14) in hematologic malignancies) have been linked to cancer, making these antibodies valuable in oncology research.

Experimental applications include immunofluorescence, immunohistochemistry, and Western blotting to visualize NUMA1's spatial-temporal localization. Its role as both a structural protein and an autoantigen underscores its dual significance in cellular biology and autoimmune pathogenesis, driving ongoing studies into its mechanisms and therapeutic implications.