PEX14抗体;PEX14 Antibody—艾普蒂

PEX14 antibodies are essential tools for studying peroxisome biology, targeting the PEX14 protein—a critical component of the peroxisomal membrane. Peroxisomes are organelles involved in lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. PEX14 plays a central role in peroxisome biogenesis by acting as a docking receptor for cytosolic PEX5. which transports matrix proteins containing a peroxisomal targeting signal (PTS1). This interaction facilitates the import of cargo proteins into the peroxisomal matrix. Antibodies against PEX14 are widely used to investigate peroxisome dynamics, dysfunction, or proliferation in various diseases, including peroxisomal disorders (e.g., Zellweger syndrome), neurodegenerative conditions, and metabolic syndromes. They enable detection of PEX14 expression levels, subcellular localization (via immunofluorescence or immunoelectron microscopy), and protein-protein interactions (via co-immunoprecipitation). Available as monoclonal or polyclonal variants, these antibodies are typically validated in assays like Western blotting, immunohistochemistry, or knockout cell line controls. Research applications also extend to studying crosstalk between peroxisomes and other organelles, such as mitochondria or the endoplasmic reticulum, highlighting PEX14's role in cellular homeostasis. Reliable PEX14 antibodies are crucial for advancing understanding of peroxisome-related pathologies and therapeutic strategies.