KIF5A抗体;KIF5A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13737(KIF5A Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The KIF5A antibody is a crucial tool in studying kinesin family member 5A (KIF5A), a neuron-specific motor protein responsible for intracellular cargo transport along microtubules. As part of the kinesin-1 subfamily, KIF5A facilitates anterograde movement of vesicles, organelles, and proteins in axons, maintaining neuronal function and survival. Its dysfunction is linked to neurodegenerative disorders like amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), where mutations in the KIF5A gene impair axonal transport mechanisms.

KIF5A antibodies are widely used to detect protein expression, localization, and interactions in research models. They enable techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation, aiding investigations into disease mechanisms. Specificity is ensured through validation in knockout cell lines or tissues, confirming minimal cross-reactivity with homologous proteins KIF5B/KIF5C.

These antibodies also support therapeutic development by identifying molecular disruptions in ALS/HSP models and evaluating potential interventions. Commercially available as monoclonal or polyclonal variants, they are typically generated against recombinant KIF5A domains or synthetic epitopes. Ongoing research leverages KIF5A antibodies to dissect cargo-binding dynamics, post-translational modifications, and compensatory mechanisms in neurodegeneration, highlighting their versatility in neuroscience and cell biology.