FERMT1抗体;FERMT1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13736(FERMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

FERMT1. also known as Kindlin-1. is a protein encoded by the FERMT1 gene and belongs to the kindlin family of focal adhesion proteins. It plays a critical role in cell-matrix adhesion, integrin activation, and cellular signaling by connecting the cytoskeleton to extracellular matrix components. Structurally, it contains a FERM domain (F0-F3 subdomains) that mediates interactions with integrin β subunits and other cytoskeletal proteins. Dysregulation of FERMT1 is linked to several pathologies, including Kindler epidermolysis bullosa, a rare autosomal recessive skin disorder characterized by skin fragility, photosensitivity, and increased cancer risk due to loss-of-function mutations.

FERMT1 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect FERMT1 in tissues or cultured cells. Researchers employ them to investigate mechanisms underlying epithelial integrity, wound healing, and cancer progression, as FERMT1 overexpression has been implicated in tumor metastasis and drug resistance in certain cancers. Additionally, FERMT1 antibodies aid in diagnosing genetic disorders like Kindler syndrome by identifying protein deficiencies in patient samples. Their specificity and validation across species make them valuable for translational research aiming to develop targeted therapies for FERMT1-related diseases.