KIF3B抗体;KIF3B Antibody—艾普蒂

The KIF3B antibody is a research tool targeting Kinesin Family Member 3B (KIF3B), a motor protein in the kinesin-2 subfamily involved in intracellular transport. KIF3B forms heterotrimeric complexes (with KIF3A and KAP3) to move cargo along microtubules, critical for cilium assembly, organelle trafficking, and signal transduction (e.g., Hedgehog, Wnt pathways). It plays roles in cell division, polarity, and neuronal development. Antibodies against KIF3B are widely used to study its expression, localization, and interactions in cellular models. Researchers employ these antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore KIF3B’s involvement in diseases, including cancers, ciliopathies, and neurodegenerative disorders. Dysregulation of KIF3B is linked to tumor progression, ciliary dysfunction, and developmental defects, making it a biomarker of interest. Commercial KIF3B antibodies are typically validated for specificity across human, mouse, and rat samples, aiding mechanistic studies of microtubule-dependent transport and disease pathways. Recent studies also investigate its role in primary cilia-related signaling, highlighting its therapeutic potential.