Spink1抗体;Spink1 Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Rat pancreas tissue lysate, Primary antibody: P13729(Spink1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 4 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13729(Spink1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13729(Spink1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SPINK1 antibody targets serine peptidase inhibitor Kazal type 1 (SPINK1), a protein encoded by the *SPINK1* gene. SPINK1. also known as pancreatic secretory trypsin inhibitor (PSTI), functions primarily to inhibit trypsin activity in the pancreas, preventing premature protease activation and tissue damage. It is expressed in pancreatic acinar cells and other tissues, including the prostate, liver, and gastrointestinal tract. Clinically, SPINK1 is linked to pancreatic disorders; mutations in the *SPINK1* gene are associated with hereditary and chronic pancreatitis. Moreover, SPINK1 overexpression is observed in several cancers (e.g., prostate, breast, and hepatocellular carcinomas), where it may promote tumor progression by modulating protease activity, cell proliferation, or apoptosis pathways.

SPINK1 antibodies are critical tools in research and diagnostics. They enable detection of SPINK1 expression via techniques like immunohistochemistry (IHC), Western blotting, or ELISA, aiding in studies of its role in disease mechanisms. Monoclonal antibodies offer high specificity for quantitative assays, while polyclonal antibodies may capture diverse epitopes in localization studies. Clinically, these antibodies help identify SPINK1 as a biomarker for pancreatitis risk stratification or cancer prognosis. Recent therapeutic strategies also explore neutralizing SPINK1 antibodies to block its oncogenic signaling. However, challenges remain in standardizing assays due to SPINK1's complex interactions and isoforms. Overall, SPINK1 antibodies are pivotal in unraveling the protein's pathophysiological roles and translational potential.