PLIN4抗体;PLIN4 Antibody—艾普蒂 新品

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13709(PLIN4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of PLIN4 Antibody**

Perilipin 4 (PLIN4), also known as S3-12. is a member of the perilipin family of lipid droplet (LD)-associated proteins that regulate lipid storage and metabolism. It is primarily expressed in adipose tissue and plays a role in stabilizing LDs, particularly during lipolysis and lipid mobilization. PLIN4 is distinct from other perilipins due to its unique structural features, including repetitive sequences that may facilitate interactions with LD surfaces.

Antibodies targeting PLIN4 are critical tools for studying its expression, localization, and function in metabolic processes. Research using PLIN4 antibodies has revealed its involvement in conditions such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). For instance, PLIN4 expression is upregulated in adipose tissue during obesity, suggesting a compensatory role in managing lipid overload.

PLIN4 antibodies are also employed to investigate its tissue-specific roles, including its contribution to hepatic lipid metabolism and potential cross-talk with other perilipin family members (e.g., PLIN1. PLIN2). Additionally, studies have explored PLIN4's relevance in cancer, where altered lipid metabolism in tumor cells may depend on LD-associated proteins.

Overall, PLIN4 antibodies serve as essential reagents for elucidating the molecular mechanisms of lipid storage diseases and metabolic disorders, offering insights for therapeutic targeting.