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网站主页 KCNN1抗体 KCNN1抗体
  • KCNN1抗体;KCNN1 Antibody—艾普蒂
  • KCNN1抗体;KCNN1 Antibody—艾普蒂
  • KCNN1抗体;KCNN1 Antibody—艾普蒂

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KCNN1抗体;KCNN1 Antibody—艾普蒂

Rabbit Polyclonal KCNN1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-28

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
KCNN1抗体
英文名称：
Rabbit Polyclonal KCNN1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 7433 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
KCNN1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCEACAM1; BGP; BGP1; BGPI
Entrez GeneID634
clone7B9G3
WB Predicted band size57.6kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD66A (AA: extra 65-201) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CD66A mouse mAb against HepG2 (1), SK-MES-1 (2), Hela (3), and A549 (4) cell lysate.    


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       Flow cytometric analysis of Hela cells using CD66A mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using CD66A mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD66A mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于KCNN1抗体的代表性文献(内容基于既往研究概括，非真实文献)：

1. **文献名称**: "Characterization of KCNN1 expression in hippocampal neurons using a novel polyclonal antibody"

**作者**: Smith J et al. (2015)

**摘要**: 开发了一种兔源多克隆抗体，通过Western blot和免疫组化验证了KCNN1(SK1通道)在海马神经元中的特异性表达，发现其在突触可塑性相关区域富集，提示其与学习记忆功能相关。

2. **文献名称**: "Dysregulation of KCNN1 in cardiac hypertrophy: Antibody-based localization analysis"

**作者**: Chen L et al. (2018)

**摘要**: 利用商业化KCNN1抗体(货号abxxxxx)研究小鼠心脏肥大模型，发现KCNN1蛋白在心肌细胞膜表达下调，可能与钙信号异常和心律失常风险增加相关。

3. **文献名称**: "KCNN1 antibody validation for single-cell RNA sequencing data in human prefrontal cortex"

**作者**: Wang Y et al. (2020)

**摘要**: 通过免疫荧光共定位实验验证某KCNN1抗体的特异性，证明其与前额叶皮层中间神经元中KCNN1 mRNA表达高度一致，支持该抗体在人类脑组织研究中的可靠性。

注：以上为模拟文献，实际引用需查询PubMed/Google Scholar等数据库，推荐使用关键词"KCNN1 antibody validation"或"SK1 channel immunohistochemistry"筛选近期研究。

       

背景信息

The KCNN1 antibody targets the KCNN1 protein, a member of the small-conductance calcium-activated potassium (SK) channel family. Encoded by the *KCNN1* gene, this channel is characterized by its calcium sensitivity mediated through calmodulin binding. KCNN1 (also known as SK1) regulates neuronal excitability and muscle contractility by contributing to the afterhyperpolarization phase of action potentials, thereby modulating cellular repolarization and firing frequency. It is predominantly expressed in the central nervous system, smooth muscle, and specific endocrine cells, playing roles in processes such as synaptic plasticity, vasodilation, and hormone secretion.

Antibodies against KCNN1 are essential tools in neuroscience and physiology research. They enable the detection, localization, and quantification of KCNN1 protein in tissues or cell lines using techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate KCNN1's distribution, expression patterns, and functional interactions in health and disease. Dysregulation of SK channels, including KCNN1. has been implicated in neurological disorders (e.g., epilepsy, ataxia), cardiovascular diseases, and metabolic syndromes. Researchers also employ KCNN1 antibodies to study channel modulation by pharmacological agents, aiding drug discovery for conditions linked to SK channel dysfunction. Validation via knockout controls or peptide-blocking assays ensures specificity, critical for reliable experimental outcomes.

       
KCNN1抗体;KCNN1;KCNN1 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

KCNN1抗体相关厂家报价

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  • 维百奥（北京）生物科技有限公司 VIP
  • 2025-12-29
  • 询价
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