KCNIP1抗体;KCNIP1 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13681(KCNIP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13681(KCNIP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The KCNIP1 (Kv Channel-Interacting Protein 1) antibody is a tool used to detect and study the KCNIP1 protein, a member of the potassium channel-interacting protein family. KCNIP1. also known as VSNL1 or DREAM, modulates the activity of voltage-gated potassium channels (Kv4 family), which regulate neuronal excitability and cardiac action potentials. It is highly expressed in the brain and heart, where it binds to Kv4 channels to influence their trafficking, kinetics, and surface expression. Beyond ion channel regulation, KCNIP1 interacts with calcium sensors (e.g., calmodulin) and transcriptional pathways, suggesting roles in calcium signaling and gene expression.

Antibodies targeting KCNIP1 are critical for elucidating its physiological and pathological roles. In research, they are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to map protein distribution, quantify expression levels, or assess post-translational modifications. Dysregulation of KCNIP1 is implicated in neurological disorders (e.g., Alzheimer’s disease, epilepsy) and cardiac arrhythmias, making it a potential biomarker or therapeutic target. However, antibody specificity must be validated, as KCNIP1 shares homology with other KChIP family members (KCNIP2-4). Recent studies also explore its interaction with amyloid-β peptides and involvement in synaptic plasticity, highlighting its multifaceted roles in health and disease.