JPH2抗体;JPH2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13666(JPH2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

JPH2 (Junctophilin-2) is a critical protein involved in maintaining the structural and functional integrity of cardiac muscle cells. It belongs to the junctophilin family, which plays a key role in forming junctional membrane complexes (JMCs) by physically linking the plasma membrane with the sarcoplasmic reticulum (SR). These complexes are essential for efficient excitation-contraction coupling (ECC), a process enabling synchronized calcium release during cardiac contraction.

JPH2 antibodies are immunological tools designed to detect and quantify JPH2 expression in research settings. They are widely used in studies exploring cardiac physiology, particularly in understanding how disruptions in JPH2 function contribute to cardiomyopathies, arrhythmias, or heart failure. For instance, JPH2 mutations or reduced expression have been associated with hypertrophic cardiomyopathy (HCM) and calcium handling abnormalities.

In research, JPH2 antibodies are applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein localization, expression levels, or post-translational modifications. Their specificity helps elucidate JPH2's role in cardiac pathologies and potential therapeutic targets. Recent studies also investigate JPH2's interaction with other ECC-related proteins, such as ryanodine receptors, further highlighting its diagnostic and mechanistic relevance in cardiovascular diseases.