ISY1-RAB43抗体;ISY1-RAB43 Antibody—艾普蒂 新品

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T, HepG2 and SKOV3 cell lysates, Primary antibody: P13652(ISY1-RAB43 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13652(ISY1-RAB43 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13652(ISY1-RAB43 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ISY1-RAB43 antibody is associated with the study of two distinct genes, ISY1 (Involved in RNA Splicing and Nuclear Transport 1) and RAB43 (RAS-associated protein 43), which play roles in cellular processes such as RNA splicing, vesicular trafficking, and intracellular transport. ISY1 is implicated in RNA splicing and spliceosome assembly, while RAB43. a member of the Rab GTPase family, regulates membrane trafficking and Golgi apparatus organization.

The ISY1-RAB43 antibody likely targets a fusion protein or interaction between these proteins, though specific literature on this exact target is limited. Such antibodies are typically developed for research purposes to explore potential gene fusions, protein interactions, or dysregulated pathways in diseases like cancer. For instance, RAB43 overexpression has been linked to certain cancers, and aberrant RNA splicing mechanisms involving ISY1 may contribute to oncogenesis.

Antibodies against ISY1 or RAB43 individually are used in immunohistochemistry, Western blotting, or immunofluorescence to study their localization, expression levels, or functional roles. However, the ISY1-RAB43 antibody’s exact application depends on its design—whether it detects a fusion product, simultaneous expression, or co-localization. Researchers utilize such tools to investigate molecular mechanisms in cellular models or disease contexts, aiming to identify therapeutic targets or biomarkers. Further studies are needed to fully characterize the ISY1-RAB43 interaction and its biological significance.