IPPK抗体;IPPK Antibody—艾普蒂

IPPK (Inositol Pentakisphosphate 2-Kinase), also known as IP5K, is an enzyme that catalyzes the phosphorylation of inositol pentakisphosphate (IP5) to produce inositol hexakisphosphate (IP6. or phytic acid), a critical molecule in eukaryotic cellular signaling and metabolism. IP6 plays roles in diverse processes, including mRNA export, DNA repair, apoptosis, and vesicular trafficking. IPPK antibodies are immunological tools designed to detect and quantify IPPK protein expression in research settings. These antibodies are essential for studying IPPK's regulatory functions, tissue-specific expression patterns, and involvement in diseases such as cancer, neurological disorders, and metabolic syndromes. For instance, altered IPPK activity has been linked to tumor progression due to IP6's role in modulating cell proliferation and genomic stability. Commercially available IPPK antibodies are typically developed using immunogenic peptides or recombinant protein fragments, validated through techniques like Western blotting, immunohistochemistry, or immunofluorescence. Challenges include ensuring specificity due to structural similarities among inositol phosphate kinases. Recent studies also explore IPPK's interaction with other signaling pathways, such as mTOR and AMPK, highlighting its potential as a therapeutic target. Researchers rely on these antibodies to dissect IPPK's contribution to cellular homeostasis and disease mechanisms, advancing drug discovery and molecular diagnostics.