HOXC13抗体;HOXC13 Antibody—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using NCAM1 mouse mAb against NIH/3T3 (1) cell lysate.    

  
  

The HOXC13 antibody is a key reagent used to study the HOXC13 protein, a member of the homeobox (HOX) family of transcription factors. HOX genes play critical roles in embryonic development, particularly in patterning body axes and regulating organogenesis. HOXC13. located on chromosome 12q13.3. is part of the HOXC cluster and is involved in hair, nail, and skin development, as well as cancer progression. It regulates gene expression by binding to specific DNA sequences, influencing cell differentiation, proliferation, and apoptosis. Dysregulation of HOXC13 has been linked to ectodermal dysplasia, trichodysplasia, and malignancies like colorectal, prostate, and breast cancers.

HOXC13 antibodies are widely used in research to detect protein expression and localization via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). They help investigate HOXC13's role in developmental biology, tissue homeostasis, and oncogenesis. Polyclonal and monoclonal HOXC13 antibodies vary in specificity; validation using knockout controls or siRNA knockdown is essential to confirm target binding. Commercial antibodies often cite applications in formalin-fixed paraffin-embedded (FFPE) tissues or cell lysates. Researchers also utilize HOXC13 antibodies in ChIP-seq to study DNA-binding interactions or in co-immunoprecipitation to identify protein partners. Given HOXC13's emerging role as a potential biomarker or therapeutic target, these antibodies are vital for advancing studies in developmental disorders, dermatopathology, and cancer biology.