HOOK3抗体;HOOK3 Antibody—艾普蒂

The HOOK3 antibody targets the HOOK3 protein, a member of the HOOK family of cytosolic coiled-coil proteins that play critical roles in intracellular trafficking and organelle positioning. HOOK3. encoded by the *HOOK3* gene in humans, acts as an adaptor linking molecular motors (e.g., dynein-dynactin complexes) to cargo vesicles, facilitating microtubule-based transport. Structurally, it contains an N-terminal microtubule-binding domain, a central coiled-coil region mediating dimerization, and a C-terminal domain for cargo interaction. HOOK3 is implicated in Golgi apparatus organization, endosomal trafficking, and synaptic vesicle recycling in neurons. It also participates in ciliogenesis, sperm development, and cellular stress responses. Dysregulation of HOOK3 has been associated with cancers (e.g., metastatic progression), neurodegenerative disorders, and male infertility. Antibodies against HOOK3 are essential tools for studying its localization, expression, and molecular interactions in these processes. They are widely used in techniques like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to explore HOOK3's role in cellular dynamics and disease mechanisms. Research utilizing HOOK3 antibodies continues to uncover its regulatory networks, aiding the development of therapeutic strategies targeting intracellular transport defects.