HNRNPUL1抗体;HNRNPUL1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela, 231 and Raji cell lysates, Primary antibody: P13587(HNRNPUL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13587(HNRNPUL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P13587(HNRNPUL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HNRNPUL1 antibody is a valuable tool for studying the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRNPUL1) protein, a member of the hnRNP family involved in RNA processing and DNA repair. HNRNPUL1 contains RNA-binding motifs and participates in diverse cellular functions, including transcriptional regulation, mRNA splicing, and maintaining genomic stability. It interacts with proteins like BRCA1. suggesting a role in DNA damage response pathways, particularly homologous recombination repair. Dysregulation of HNRNPUL1 has been linked to cancers, such as hepatocellular carcinoma and breast cancer, where its overexpression may promote tumor progression or metastasis.

Researchers use HNRNPUL1 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression patterns, subcellular localization (primarily nuclear, with stress-induced cytoplasmic shifts), and protein-protein interactions. These studies help elucidate its mechanistic roles in disease contexts. Commercially available antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Challenges include optimizing experimental conditions due to potential cross-reactivity with homologous hnRNP family members. Ongoing research focuses on HNRNPUL1's potential as a diagnostic biomarker or therapeutic target, particularly in DNA repair-deficient cancers.