HPCA抗体;HPCA Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13572(HPCA Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P13572(HPCA Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

**Background of HPCA Antibody**

Hippocalcin (HPCA), a calcium-sensing protein predominantly expressed in the brain, belongs to the neuronal calcium sensor (NCS) family. It plays a critical role in regulating intracellular calcium signaling, synaptic plasticity, and neuronal excitability. HPCA is particularly abundant in hippocampal neurons, where it modulates calcium-dependent processes linked to learning, memory, and neuroprotection. Dysregulation of HPCA has been implicated in neurological disorders, including epilepsy, Alzheimer’s disease, and ischemic brain injury.

HPCA antibodies are essential tools for investigating its expression, localization, and function in both physiological and pathological contexts. These antibodies are typically developed using immunogenic peptides derived from conserved regions of the HPCA protein, enabling specificity in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers utilize HPCA antibodies to study its interaction with downstream targets (e.g., ion channels, kinases) and its role in calcium buffering or apoptosis. Recent studies also explore HPCA’s potential as a biomarker for neurodegenerative diseases.

The development and validation of HPCA antibodies have advanced understanding of calcium-mediated signaling pathways in the brain, offering insights into therapeutic strategies for neurological conditions. Commercial HPCA antibodies are often validated across species, including human, mouse, and rat models, ensuring broad applicability in neuroscience research.