HIC1抗体;HIC1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer using P13571(HIC1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer using P13571(HIC1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The HIC1 (Hypermethylated in Cancer 1) antibody is a tool used to detect the HIC1 protein, a zinc-finger transcriptional repressor encoded by the *HIC1* gene. Initially identified as a tumor suppressor, HIC1 is frequently epigenetically silenced in human cancers through promoter hypermethylation, a hallmark of its inactivation. It regulates diverse cellular processes, including cell cycle arrest, apoptosis, and DNA damage response, often in coordination with p53. HIC1 also plays roles in embryonic development, particularly in neural and cardiovascular systems.

HIC1 antibodies are widely employed in cancer research to study its expression patterns, subcellular localization, and interactions. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and chromatin immunoprecipitation (ChIP), aiding in the exploration of HIC1's role in tumor suppression and gene regulatory networks. Researchers also use them to investigate HIC1's involvement in chromatin remodeling and transcriptional repression through associations with complexes like Polycomb. Validation of antibody specificity via knockout controls is critical, as cross-reactivity with other zinc-finger proteins may occur. The antibody's utility extends to clinical studies, where loss of HIC1 expression correlates with poor prognosis in various cancers, highlighting its potential as a diagnostic or therapeutic biomarker.