HECTD2抗体;HECTD2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain using P13566(HECTD2 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The HECTD2 antibody is a research tool designed to detect and study the HECT domain-containing protein 2 (HECTD2), a member of the HECT (Homologous to E6-AP C-Terminus) family of E3 ubiquitin ligases. These enzymes play a critical role in the ubiquitin-proteasome system by catalyzing the transfer of ubiquitin to substrate proteins, marking them for degradation or modulating their function. HECTD2 is implicated in diverse cellular processes, including protein quality control, signal transduction, and immune regulation. However, its precise biological roles and substrates remain poorly characterized compared to other HECT family members.

HECTD2 antibodies are primarily used in Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions in various tissues and cell lines. Studies have linked HECTD2 to neurodevelopmental disorders, cancer progression, and autoimmune diseases, though mechanistic insights are limited. For instance, some research suggests its involvement in endoplasmic reticulum-associated degradation (ERAD) pathways or immune response modulation via ubiquitination of signaling molecules.

The development and validation of HECTD2 antibodies are essential for elucidating its physiological and pathological functions. Commercial antibodies are typically raised against specific epitopes, often in the N-terminal or C-terminal regions, and require rigorous validation for specificity and cross-reactivity. Ongoing research aims to clarify HECTD2's role in disease mechanisms, potentially identifying it as a therapeutic target. Despite progress, further studies are needed to map its interactome and regulatory networks in health and disease.