RGR抗体;RGR Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P13560(RGR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13560(RGR Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

RGR (Retinal G-protein coupled Receptor) antibody is a research tool targeting RGR, a retinal protein belonging to the G-protein coupled receptor (GPCR) family. First identified in the 1990s, RGR is predominantly expressed in retinal pigment epithelium (RPE) and Müller cells, where it plays a role in visual chromophore regeneration and phototransduction. Unlike typical opsins, RGR functions in a light-dependent manner to isomerize all-trans-retinol to 11-cis-retinol, a critical step in recycling visual pigments during the retinoid cycle. This activity links RGR to the maintenance of photoreceptor function and overall retinal homeostasis.

Research on RGR antibodies has grown due to their utility in studying retinal degenerative diseases. Mutations in the RGR gene are associated with inherited retinal disorders, including retinitis pigmentosa and cone-rod dystrophy. Antibodies against RGR enable immunohistochemical localization, protein quantification, and investigation of RGR’s interaction with retinoid-binding proteins. Recent studies also explore RGR’s potential role in age-related macular degeneration (AMD) and its response to oxidative stress.

Commercial RGR antibodies are typically developed in rabbit or mouse hosts, validated via Western blotting and immunofluorescence. Challenges include ensuring specificity due to structural similarities among GPCRs. Ongoing work aims to refine antibody performance for therapeutic discovery and mechanistic studies of RGR-related pathways in vision and disease.