SNRPG抗体;SNRPG Antibody—艾普蒂

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat and 293T cell lysates, Primary antibody: P13558(SNRPG Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13558(SNRPG Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of SNRPG Antibody**

SNRPG (Small Nuclear Ribonucleoprotein Polypeptide G) is a core component of the spliceosome, a dynamic macromolecular complex essential for pre-mRNA splicing in eukaryotic cells. The spliceosome assembles on pre-mRNA through the interaction of small nuclear ribonucleoproteins (snRNPs) and auxiliary proteins. SNRPG, also known as Sm G, is part of the Sm protein family, which forms a heptameric ring structure that binds to uridine-rich regions of snRNAs (e.g., U1. U2. U4. U5) to stabilize snRNP complexes. This stabilization is critical for spliceosome assembly and catalytic activity during the removal of introns.

Antibodies targeting SNRPG are widely used in molecular biology research to study spliceosome dynamics, RNA processing mechanisms, and their dysregulation in diseases. For example, aberrant splicing due to spliceosome defects has been linked to cancers, neurodegenerative disorders, and autoimmune conditions. SNRPG antibodies enable detection of the protein in techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the analysis of its expression, localization, and interactions.

Additionally, SNRPG autoantibodies have been reported in some autoimmune diseases, such as systemic lupus erythematosus (SLE), where immune responses mistakenly target snRNP components. Studying SNRPG with specific antibodies thus contributes to both basic research on RNA metabolism and clinical investigations into disease biomarkers or therapeutic targets.