GNGT2抗体;GNGT2 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13557(GNGT2 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The GNGT2 antibody targets the gamma subunit of the heterotrimeric G-protein complex, specifically the Gγ2 protein encoded by the GNGT2 gene. This subunit plays a critical role in signal transduction by coupling G-protein-coupled receptors (GPCRs) to intracellular effectors. GNGT2 is predominantly expressed in retinal photoreceptors, where it participates in phototransduction pathways by interacting with transducin (Gt) to regulate light-induced signaling. Its function is essential for visual signal amplification and adaptation in rod and cone cells.

Antibodies against GNGT2 are valuable tools for studying retinal biology, GPCR signaling mechanisms, and diseases linked to photoreceptor dysfunction, such as retinitis pigmentosa or congenital stationary night blindness. They are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize GNGT2 expression or assess its protein levels in experimental models.

Commercial GNGT2 antibodies are typically validated for specificity using knockout controls or peptide-blocking assays. Researchers should verify cross-reactivity across species (e.g., human, mouse) and consider tissue-specific expression patterns. Dysregulation of GNGT2 has also been explored in non-retinal contexts, including certain cancers, though its broader physiological roles remain under investigation. Proper antibody selection ensures accurate interpretation of GNGT2's contribution to cellular signaling and disease pathways.