HSF2BP抗体;HSF2BP Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13552(HSF2BP Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13552(HSF2BP Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HSF2BP (Heat Shock Factor 2 Binding Protein) antibody is a tool used to detect and study the HSF2BP protein, which plays a crucial role in DNA repair and genomic stability. HSF2BP interacts with heat shock factor 2 (HSF2), a transcription factor involved in stress response and developmental processes. Research has shown that HSF2BP is essential for homologous recombination repair (HRR), a critical mechanism for resolving DNA double-strand breaks, particularly during meiosis. Its function is closely linked to germ cell development, with studies implicating HSF2BP mutations in male infertility due to impaired spermatogenesis.

The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate HSF2BP expression, localization, and interaction partners. Recent studies highlight its relevance in cancer research, as dysregulation of HRR pathways may contribute to tumorigenesis and therapy resistance. Additionally, HSF2BP antibodies aid in exploring molecular mechanisms underlying conditions like azoospermia, where HSF2BP deficiency disrupts meiotic progression. As a research reagent, it supports both basic science and clinical investigations into DNA repair disorders, reproductive health, and potential therapeutic targets.