HABP4抗体;HABP4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13548(HABP4 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13548(HABP4 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The hyaluronan-binding protein 4 (HABP4), also known as HYAL4. is a member of the hyaluronidase family involved in hyaluronan metabolism, which plays roles in extracellular matrix remodeling, cell signaling, and cancer progression. HABP4/HYAL4 is characterized by its ability to bind and degrade hyaluronic acid (HA), a glycosaminoglycan critical for tissue hydration, cell motility, and angiogenesis. Dysregulation of HABP4 has been implicated in tumorigenesis, with studies suggesting its overexpression in certain cancers, where it may promote tumor growth, metastasis, and vascularization by modulating HA turnover and interactions with cell surface receptors like CD44.

HABP4 antibodies are essential tools for detecting and quantifying HABP4 protein expression in research. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its localization in tissues or cultured cells. These antibodies help elucidate HABP4’s role in pathological conditions, including cancer, osteoarthritis, and inflammatory diseases. Most HABP4 antibodies target specific epitopes within its N-terminal or C-terminal domains and are validated for specificity using knockout controls. Researchers also employ them to investigate post-translational modifications or interactions with HA and other extracellular matrix components. Commercial HABP4 antibodies are typically raised in rabbits or mice, with validation data confirming reactivity across human, mouse, and rat samples.