GUCY1B2抗体;GUCY1B2 Antibody—艾普蒂 新品

The GUCY1B2 antibody is designed to target the guanylate cyclase 1 soluble subunit beta 2 (GUCY1B2), a component of the soluble guanylate cyclase (sGC) enzyme complex. sGC plays a critical role in the nitric oxide (NO) signaling pathway by catalyzing the conversion of GTP to cyclic guanosine monophosphate (cGMP), a secondary messenger involved in vasodilation, neurotransmission, and cellular homeostasis. GUCY1B2 pairs with an alpha subunit (e.g., GUCY1A1 or GUCY1A2) to form functional heterodimers, which are activated by NO binding to their heme moiety. Dysregulation of sGC activity has been implicated in cardiovascular diseases, pulmonary hypertension, and neurodegenerative disorders. The GUCY1B2 antibody is utilized in research to study protein expression, localization, and functional interactions in tissues or cell models, particularly in contexts exploring NO-cGMP pathway disruptions. Its applications include techniques like Western blotting, immunohistochemistry, and immunofluorescence. Understanding GUCY1B2's role may aid in developing therapeutics targeting sGC for conditions like hypertension or heart failure. Specificity and validation of the antibody are critical, as cross-reactivity with other sGC subunits can complicate interpretations.