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  • LDHA抗体;LDHA Antibody—艾普蒂
  • LDHA抗体;LDHA Antibody—艾普蒂
  • LDHA抗体;LDHA Antibody—艾普蒂

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LDHA抗体;LDHA Antibody—艾普蒂

Rabbit Polyclonal LDHA Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-28

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
LDHA抗体
英文名称：
Rabbit Polyclonal LDHA Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 7323 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
LDHA

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesLDHM; GSD11; PIG19; HEL-S-133P
WB Predicted band size37 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human LDHA
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 and Hela cell lysates, Primary antibody: P13499(LDHA Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P13499(LDHA Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P13499(LDHA Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于LDHA抗体的3篇示例参考文献(文献为虚构示例，仅作格式参考)：

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1. **文献名称**: *LDHA overexpression correlates with poor prognosis in colorectal cancer: an immunohistochemical study*

**作者**: Zhang Y., Li X., Wang H. et al.

**摘要**: 本研究通过免疫组化技术分析LDHA在结直肠癌组织中的表达水平，发现LDHA在肿瘤细胞中显著高表达，且与患者的总生存期缩短和转移风险增加相关，提示LDHA可作为潜在的预后生物标志物。

2. **文献名称**: *Targeting LDHA with a monoclonal antibody inhibits glycolysis and suppresses tumor growth in pancreatic cancer models*

**作者**: Smith R.L., Brown K.T., Garcia M. et al.

**摘要**: 开发了一种靶向LDHA的单克隆抗体，并在胰腺癌小鼠模型中验证其疗效。结果显示，该抗体通过抑制糖酵解通路减少乳酸生成，显著抑制肿瘤生长，为LDHA靶向治疗提供了实验依据。

3. **文献名称**: *LDHA-mediated metabolic reprogramming in tumor-associated macrophages promotes immunosuppression*

**作者**: Chen L., Wei F., Patel N. et al.

**摘要**: 研究利用LDHA抗体阻断肿瘤相关巨噬细胞(TAMs)中的LDHA活性，发现其可逆转TAMs的免疫抑制表型，增强T细胞抗肿瘤反应，揭示了LDHA在肿瘤微环境代谢调控中的关键作用。

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**注**：以上文献为模拟示例，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。

       

背景信息

LDHA (Lactate Dehydrogenase A) is a critical enzyme in the glycolytic pathway, catalyzing the conversion of pyruvate to lactate under anaerobic conditions. It plays a pivotal role in cellular energy metabolism, particularly in cancer cells that rely on the Warburg effect—a metabolic shift favoring glycolysis even in the presence of oxygen. Overexpression of LDHA is associated with tumor progression, metastasis, and poor prognosis, making it a potential therapeutic target and biomarker in oncology.

LDHA antibodies are immunological tools designed to detect and quantify LDHA protein levels in various biological samples. They are widely used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study LDHA expression patterns in cancer, metabolic disorders, and other diseases. These antibodies aid in elucidating LDHA's role in cellular metabolism, hypoxia response, and drug resistance mechanisms.

Commercially available LDHA antibodies are typically validated for specificity and sensitivity across species (e.g., human, mouse, rat) and sample types. Their development has accelerated studies exploring LDHA inhibition as a cancer treatment strategy and its involvement in non-oncological conditions like sepsis or neurodegenerative diseases. Proper validation, including knockout controls, is essential to ensure antibody reliability in experimental settings.

       
LDHA抗体;LDHA;LDHA Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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