CHP1抗体;CHP1 Antibody—艾普蒂 新品

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue lysate, Primary antibody: P13490(CHP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13490(CHP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13490(CHP1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

CHP1 (Calcineurin Homologous Protein 1) is a calcium-binding protein belonging to the CHP family, initially identified through its homology to the regulatory subunit of calcineurin. It functions as a critical co-factor for sodium-hydrogen exchangers (NHEs), particularly NHE1. by stabilizing their expression, regulating intracellular pH, and maintaining ion homeostasis. Structurally, CHP1 contains EF-hand motifs that bind Ca²⁺ or Mg²⁺, enabling its interaction with target proteins and modulation of their activity.

Originally linked to cellular processes such as proliferation, migration, and apoptosis, CHP1 has since been implicated in diverse signaling pathways, including Ras-MAPK and PI3K/Akt, which influence cancer progression, neurodegeneration, and cardiovascular diseases. Studies highlight its dual role in tumorigenesis, acting as either an oncogene or tumor suppressor depending on cellular context. For instance, CHP1 overexpression is observed in certain cancers (e.g., breast, colorectal), while its downregulation correlates with poor prognosis in others.

CHP1 antibodies are widely used in research to detect endogenous CHP1 expression, subcellular localization (e.g., cytoplasmic or membrane-associated), and interactions with NHE1 or other partners via techniques like Western blot, immunofluorescence, or co-immunoprecipitation. These tools have advanced understanding of CHP1's pathophysiological roles and its potential as a therapeutic target. Dysregulation of CHP1 has also been associated with neurological disorders, including Alzheimer’s disease, emphasizing its broad biological relevance.