GPR132抗体;GPR132 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13480(GPR132 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of GPR132 Antibody**

GPR132 (G protein-coupled receptor 132), also known as G2A, is a pH-sensing receptor belonging to the G protein-coupled receptor (GPCR) family. It is implicated in immune regulation, inflammation, and cancer progression. Structurally, it contains seven transmembrane domains and extracellular loops critical for ligand interaction. GPR132 is activated by lysophosphatidylcholine (LPC) and oxidized free fatty acids, functioning as a pH-dependent receptor in response to acidic microenvironments. It is highly expressed in immune cells, including macrophages and lymphocytes, and plays roles in phagocytosis (efferocytosis), apoptosis, and lipid metabolism.

Antibodies targeting GPR132 are essential tools for studying its expression, localization, and signaling mechanisms. They enable detection of GPR132 in tissues or cell lines via techniques like Western blot, immunohistochemistry, and flow cytometry. Research using GPR132 antibodies has linked the receptor to diseases such as atherosclerosis, metabolic disorders, and cancer, where it may regulate tumor-associated inflammation or metastasis. However, antibody specificity remains a challenge, requiring validation through knockout controls. Current studies focus on developing therapeutic or diagnostic applications by modulating GPR132 activity, though its precise physiological and pathological roles are still under investigation.