GLS2抗体;GLS2 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P13465(GLS2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13465(GLS2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13465(GLS2 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The GLS2 antibody is a tool used to detect glutaminase 2 (GLS2), a key enzyme in cellular metabolism. GLS2 catalyzes the conversion of glutamine to glutamate, a critical step in the glutaminolysis pathway that supports energy production, nucleotide synthesis, and redox balance. Unlike its isoform GLS1. which is often associated with cancer cell proliferation, GLS2 is primarily expressed in liver and brain tissues and has dual roles as a metabolic regulator and tumor suppressor. It is transcriptionally regulated by p53. linking it to stress responses and apoptosis.

Research using GLS2 antibodies has revealed its involvement in various physiological and pathological processes. In hepatocellular carcinoma, GLS2 downregulation correlates with poor prognosis, while its overexpression can inhibit tumor growth. Additionally, GLS2’s role in mitigating oxidative stress and maintaining mitochondrial function highlights its importance in neurodegenerative diseases.

The antibody is widely used in techniques like Western blot, immunohistochemistry, and immunofluorescence to study GLS2 expression patterns, subcellular localization, and interactions. Its specificity for distinguishing GLS2 from other isoforms makes it valuable for exploring tissue-specific metabolic adaptations and therapeutic targeting in cancer and metabolic disorders.