GIGYF1抗体;GIGYF1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain using P13462(GIGYF1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The GIGYF1 (Grb10-Interacting GYF Protein 1) antibody is a tool used to study the GIGYF1 protein, a member of the GIGYF protein family characterized by a conserved glycine-tyrosine-phenylalanine (GYF) domain. GIGYF1 interacts with Grb10 (Growth Factor Receptor-Bound Protein 10), a adaptor protein involved in insulin/IGF-1 signaling pathways. This interaction is thought to modulate receptor tyrosine kinase (RTK) signaling, particularly influencing cellular processes like growth, metabolism, and survival. Dysregulation of GIGYF1 has been implicated in neurological disorders, including Parkinson’s disease, and cancer, where altered signaling pathways contribute to tumor progression.

GIGYF1 antibodies are primarily used in research to detect and quantify GIGYF1 expression via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. They also facilitate studies on protein-protein interactions, subcellular localization, and post-translational modifications. Commercially available GIGYF1 antibodies are typically raised in rabbits or mice, with validation in specific experimental models. Researchers utilize these antibodies to explore GIGYF1’s role in cellular stress responses, autophagy, and its potential as a biomarker or therapeutic target. However, variability in antibody specificity and cross-reactivity with homologous proteins (e.g., GIGYF2) necessitates careful validation for experimental accuracy.