MBOAT4抗体;MBOAT4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13461(MBOAT4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13461(MBOAT4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

Membrane-bound O-acyltransferase domain-containing 4 (MBOAT4), also known as lysophosphatidylserine acyltransferase 1 (LPSAT1), is an enzyme involved in lipid metabolism, specifically catalyzing the transfer of acyl groups to lysophosphatidylserine to form phosphatidylserine. This process is critical for maintaining membrane phospholipid composition and cellular signaling. Dysregulation of MBOAT4 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making it a subject of growing research interest.

Antibodies targeting MBOAT4 are essential tools for studying its expression, localization, and functional roles. These antibodies are typically developed using immunogens derived from conserved regions of the human MBOAT4 protein and validated through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specificity is confirmed using knockout cell lines or tissues. Researchers employ MBOAT4 antibodies to investigate its tissue distribution, particularly in the liver, brain, and adipose tissue, as well as its altered expression in pathological conditions such as non-alcoholic fatty liver disease (NAFLD) or glioblastoma. Additionally, these antibodies aid in exploring MBOAT4's interaction networks and regulatory mechanisms in lipid homeostasis. Recent studies also assess its potential as a therapeutic target or biomarker, driving demand for reliable detection reagents. Commercial MBOAT4 antibodies often include validation data to ensure reproducibility across experimental models.