GFI1B抗体;GFI1B Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13459(GFI1B Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The GFI1B antibody is a critical tool in studying the Growth Factor Independent 1B (GFI1B) protein, a zinc finger transcriptional repressor pivotal in hematopoiesis. GFI1B regulates the development and differentiation of erythroid and megakaryocytic lineages by modulating gene expression through chromatin remodeling. It is essential for maintaining hematopoietic stem cell quiescence and preventing premature differentiation. Mutations in *GFI1B* are linked to disorders like thrombocytopenia, bleeding diatheses, and myelodysplasia, highlighting its role in blood cell homeostasis.

The antibody enables detection of GFI1B in various experimental settings, including Western blotting, immunofluorescence, and flow cytometry, aiding in research on its expression patterns and interactions. Studies using GFI1B antibodies have elucidated its involvement in repressing target genes (e.g., *TAL1*, *GATA1*) and its partnership with co-repressors like LSD1. Dysregulation of GFI1B is also implicated in leukemia, making its antibody valuable in oncology research for probing disease mechanisms or therapeutic targets.

Validating GFI1B antibodies requires specificity checks via knockout controls, as cross-reactivity with homologous proteins (e.g., GFI1) can occur. Its applications span basic research, diagnostic assays for genetic blood disorders, and drug development, underscoring its versatility in both clinical and laboratory contexts.