CXCL6抗体;CXCL6 Antibody—艾普蒂 新品

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13454(CXCL6 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

CXCL6 (C-X-C motif chemokine ligand 6), also known as granulocyte chemotactic protein-2 (GCP-2), is a small cytokine belonging to the CXC chemokine family. It plays a critical role in neutrophil chemotaxis, angiogenesis, and inflammation by interacting with its receptors, CXCR1 and CXCR2. CXCL6 is implicated in various pathological conditions, including chronic inflammatory diseases, cancer progression, and tissue repair.

CXCL6 antibodies are essential tools for detecting and analyzing the expression, localization, and function of CXCL6 in research. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and ELISA, helping to elucidate CXCL6's role in disease mechanisms. For instance, elevated CXCL6 levels are linked to tumor aggressiveness in cancers such as colorectal and lung cancer, making its antibody valuable in oncology studies.

Commercially available CXCL6 antibodies are typically monoclonal or polyclonal, with specificity validated through knockout controls or neutralizing assays. Researchers also use neutralizing antibodies to block CXCL6-receptor interactions, exploring therapeutic potential in inflammatory disorders or cancer. However, challenges remain, including cross-reactivity with homologous chemokines (e.g., CXCL5) and variability in performance across experimental models.

Overall, CXCL6 antibodies serve as pivotal reagents in both basic research and drug development, advancing understanding of chemokine-mediated pathways and their clinical relevance.