GBP4抗体;GBP4 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13450(GBP4 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P13450(GBP4 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

**Background of GBP4 Antibody**

Guanylate-binding protein 4 (GBP4) belongs to the guanylate-binding protein (GBP) family, a group of interferon (IFN)-inducible GTPases critical in host defense against intracellular pathogens. GBPs are part of the dynamin superfamily and play roles in cell-autonomous immunity, inflammasome activation, and pathogen clearance. GBP4. encoded by the *GBP4* gene in humans, is induced by IFN-γ and other proinflammatory cytokines, linking it to innate immune responses.

Structurally, GBP4 contains a globular GTPase domain and mediates membrane interactions, potentially aiding in disrupting pathogen-containing vacuoles or facilitating immune signaling. While its exact mechanisms remain less characterized compared to other GBPs (e.g., GBP1 or GBP5), studies suggest GBP4 may regulate autophagy, cytokine production, or antimicrobial pathways. Dysregulation of GBP4 has been implicated in inflammatory diseases, viral infections, and cancer, highlighting its dual role in immunity and pathology.

GBP4 antibodies are essential tools for detecting and studying GBP4 expression, localization, and function in immune cells or tissues. They enable applications like Western blotting, immunofluorescence, and flow cytometry, aiding research into GBP4's role in infection models, autoimmune disorders, and tumor microenvironments. These antibodies also support investigations into how GBP4 interacts with other immune proteins or pathogens, advancing our understanding of its therapeutic potential.