GABPB1抗体;GABPB1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cell and Mouse thymus tissue lysates, Primary antibody: P13438(GABPB1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P13438(GABPB1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

GABPB1 (GA-binding protein transcription factor subunit beta-1) is a member of the ETS (E26 transformation-specific) family of transcription factors. It forms a heterodimer with GABPA (GA-binding protein alpha subunit) to regulate genes containing GA-binding promoter elements. This complex plays a critical role in mitochondrial function, cell cycle progression, and cellular metabolism by activating genes involved in oxidative phosphorylation (e.g., COX4I1. TFAM) and ribosomal biogenesis. GABPB1 is ubiquitously expressed, with notable activity in tissues with high energy demands, such as the brain, heart, and skeletal muscle.

Antibodies targeting GABPB1 are essential tools for studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting (WB), immunofluorescence (IF), chromatin immunoprecipitation (ChIP), and co-immunoprecipitation (Co-IP) to investigate its role in transcriptional regulation and disease mechanisms. Dysregulation of GABPB1 has been implicated in cancer, neurodegenerative disorders, and metabolic syndromes, making its antibody a valuable reagent for both basic research and clinical studies. Commercial GABPB1 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown, ensuring reliability in detecting endogenous protein levels across experimental models.