FUBP1抗体;FUBP1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P13430(FUBP1 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P13430(FUBP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13430(FUBP1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The Far Upstream Element-Binding Protein 1 (FUBP1) is a multifunctional DNA/RNA-binding protein involved in transcriptional and post-transcriptional regulation. It binds to the far upstream element (FUSE) of target genes, such as the proto-oncogene MYC, to modulate their expression by unwinding DNA or RNA secondary structures. FUBP1 plays critical roles in cell cycle progression, proliferation, and differentiation. Dysregulation of FUBP1 is linked to various cancers, including gliomas, hepatocellular carcinoma, and lung cancer, where its overexpression or mutation often correlates with tumor aggressiveness and poor prognosis.

FUBP1 antibodies are essential tools for studying its function and mechanisms in both normal and pathological states. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect FUBP1 expression levels, subcellular localization, and interaction partners. Researchers also utilize FUBP1 antibodies to explore its role in oncogenesis, particularly its interplay with MYC and other oncogenic pathways. Structural studies using these antibodies have helped map functional domains, such as its KH domains responsible for nucleic acid binding. Additionally, FUBP1 antibodies contribute to biomarker discovery and therapeutic targeting strategies in cancer research. Validation of specificity through knockout controls or siRNA knockdown remains crucial due to potential cross-reactivity with homologous proteins like FUBP2/3.