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FOXQ1抗体;FOXQ1 Antibody—艾普蒂新品

Rabbit Polyclonal FOXQ1 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

上海更新日期：2025-05-28

上海切尔齐生物科技有限公司

VIP1年

联系人：周经理

电话：027-19371278702拨打

手机：18008634902 拨打

邮箱：nuodina88@163.com

产品详情:

中文名称：: FOXQ1抗体

英文名称：: Rabbit Polyclonal FOXQ1 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 7274 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: FOXQ1

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/25-1/50	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	HFH1
WB Predicted band size	42 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human FOXQ1
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue lysate, Primary antibody: P13426(FOXQ1 Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 minutes
The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P13426(FOXQ1 Antibody) at dilution 1/30. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P13426(FOXQ1 Antibody) at dilution 1/30. (Original magnification: ×200)

参考文献

1. **文献名称**：*FOXQ1 promotes colorectal cancer metastasis through upregulation of Snail*

**作者**：Zhang H. et al.

**摘要**：该研究利用FOXQ1抗体通过免疫组化分析发现，FOXQ1在结直肠癌中高表达，并通过激活Snail蛋白促进肿瘤转移，提示其作为预后标志物的潜力。

2. **文献名称**：*FOXQ1 regulates epithelial-mesenchymal transition in breast cancer via Wnt/β-catenin signaling*

**作者**：Wang Y. et al.

**摘要**：研究通过Western blot和免疫荧光技术(使用FOXQ1抗体)证实，FOXQ1通过调控Wnt通路驱动乳腺癌上皮-间质转化(EMT)，促进侵袭和转移。

3. **文献名称**：*FOXQ1 as a novel therapeutic target in gastric cancer stem-like cells*

**作者**：Li X. et al.

**摘要**：利用FOXQ1抗体进行流式细胞术和ChIP实验，揭示FOXQ1在胃癌干细胞中高表达，并通过调控Sox2维持干性，为靶向治疗提供依据。

4. **文献名称**：*FOXQ1 inhibits apoptosis in hepatocellular carcinoma by transcriptionally activating Bcl-2*

**作者**：Chen L. et al.

**摘要**：通过免疫组化(FOXQ1抗体)和双荧光素酶报告基因实验，证明FOXQ1通过上调Bcl-2抑制肝癌细胞凋亡，促进肿瘤耐药性。

背景信息

The FOXQ1 antibody is a crucial tool for studying the FOXQ1 protein, a member of the Forkhead box (FOX) transcription factor family. FOXQ1. encoded by the *FOXQ1* gene, regulates gene expression by binding to DNA via its conserved forkhead domain. It plays pivotal roles in embryonic development, cell differentiation, and tissue homeostasis. Recent research highlights its involvement in cancer progression, particularly in epithelial-mesenchymal transition (EMT), metastasis, and chemoresistance. Overexpression of FOXQ1 is linked to aggressive phenotypes in colorectal, breast, and gastric cancers, making it a potential prognostic biomarker and therapeutic target.

FOXQ1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect FOXQ1 expression and localization in tissues or cell lines. These antibodies aid in elucidating FOXQ1's molecular mechanisms, such as its interaction with Wnt/β-catenin and TGF-β signaling pathways. Commercial FOXQ1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal regions). Validation includes knockout cell controls and recombinant protein assays to ensure specificity.

Research utilizing FOXQ1 antibodies continues to expand, offering insights into its dual roles as an oncogene or tumor suppressor, depending on context. This underscores the antibody's importance in both basic research and clinical applications.

FOXQ1抗体;FOXQ1;FOXQ1 Antibody;

公司简介

生物技术有限公司

成立日期	(2年)
注册资本	20万人民币
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	抗体,植物生物技术,细胞培养,蛋白组学