FNBP1L抗体;FNBP1L Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue, Human cerebrum tissue lysates, Primary antibody: P13420(FNBP1L Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P13420(FNBP1L Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13420(FNBP1L Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The FNBP1L (Formin Binding Protein 1-Like) antibody is a tool used to study the FNBP1L protein, which plays roles in cytoskeletal regulation, membrane trafficking, and cell signaling. FNBP1L contains an FCH domain and two SH3 domains, enabling interactions with proteins like formins, which are critical for actin polymerization and cell shape dynamics. It is implicated in processes such as endocytosis, cell migration, and neuronal development, with studies linking it to Huntington's disease via interactions with huntingtin.

FNBP1L antibodies are typically developed in hosts like rabbits or mice, validated for applications such as Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help researchers investigate FNBP1L's localization, expression levels, and molecular partnerships in normal and diseased tissues. Dysregulation of FNBP1L has been observed in cancers and neurological disorders, making it a potential biomarker or therapeutic target.

Commercial FNBP1L antibodies often undergo specificity checks (e.g., knockout validation) to ensure reliability. Their use advances understanding of cellular mechanics, disease mechanisms, and pathways involving membrane-cytoskeleton crosstalk, supporting both basic research and drug discovery efforts.