RNF207抗体;RNF207 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13418(RNF207 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The RNF207 antibody is a research tool designed to detect and study the Ring Finger Protein 207 (RNF207), an E3 ubiquitin ligase involved in protein ubiquitination and degradation. RNF207 plays a critical role in regulating cardiac function, particularly in maintaining ion channel stability and electrical activity in cardiomyocytes. It has been implicated in cardiac arrhythmias, such as Brugada syndrome, by modulating the degradation of proteins like SCN5A-encoded Nav1.5 sodium channels. Dysregulation of RNF207 is also associated with heart failure and metabolic disorders, highlighting its importance in cardiovascular health.

The antibody, typically generated in hosts like rabbits or mice, enables the detection of RNF207 in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It aids in elucidating RNF207's expression patterns, subcellular localization, and interactions with other proteins. Researchers utilize this tool to explore its role in ubiquitin-mediated proteolysis, cardiac pathophysiology, and potential therapeutic targets. Commercial RNF207 antibodies are often validated for specificity and sensitivity, targeting specific epitopes or post-translational modifications. As a molecular probe, it contributes to advancing understanding of cellular protein quality control mechanisms and disease mechanisms linked to RNF207 dysfunction.