FANCB抗体;FANCB Antibody—艾普蒂

The FANCB antibody is a crucial tool for studying the FANCB protein, a key component of the Fanconi anemia (FA) DNA repair pathway. FANCB, encoded by the X-linked *FANCB* gene, is part of the FA core complex, which activates the monoubiquitination of FANCD2/FANCI to initiate repair of DNA interstrand crosslinks (ICLs). Mutations in *FANCB* cause Fanconi anemia, a rare genetic disorder marked by bone marrow failure, congenital abnormalities, and heightened cancer susceptibility. As one of the few X-linked FA genes, FANCB deficiency primarily affects males but can also manifest in females due to skewed X-inactivation. The FANCB antibody is widely used in research to detect protein expression, assess its localization (e.g., nuclear foci formation upon DNA damage), and investigate FA pathway dysfunction in cellular models. It aids in diagnosing FA subtypes and elucidating mechanisms underlying genomic instability and ICL repair. Additionally, studies employ FANCB antibodies to explore links between FA pathway defects and cancer biology, particularly in hematologic malignancies and solid tumors. Its role in identifying therapeutic targets or biomarkers for FA-related conditions further underscores its relevance in translational research.